MCQ Quiz

1. The most common intracranial tumor in adults is:

Meningioma

Metastatic tumor

Glioblastoma multiforme

Oligodendroglioma

Explanation:
Metastatic tumors are more common than all primary brain tumors combined in adults.

2. The most common intracranial tumor in children is:

Medulloblastoma

Ependymoma

Astrocytoma

Craniopharyngioma

Explanation:
Astrocytomas are the most common intracranial tumors in children.

3. Tumors that characteristically spread through cerebrospinal fluid include:

Ependymoma

Meningioma

Schwannoma

Oligodendroglioma

Explanation:
Ependymomas can disseminate via CSF pathways, producing drop metastases.

4. Homer-Wright rosettes are most characteristic of:

Ependymoma

Oligodendroglioma

Central neurocytoma

Medulloblastoma

Explanation:
Medulloblastoma shows Homer-Wright rosettes with a neurofibrillary center.

5. A “fried-egg” appearance on histology is typical of:

Oligodendroglioma

Astrocytoma

Ependymoma

Glioblastoma

Explanation:
Oligodendrogliomas show small uniform cells with clear cytoplasm producing a fried-egg appearance.

6. The genetic alteration that predicts good treatment response in oligodendroglioma is:

TP53 mutation

1p/19q co-deletion

EGFR amplification

MYC amplification

Explanation:
1p/19q co-deletion predicts better prognosis and good response to therapy.

7. The most important histologic feature that distinguishes glioblastoma from anaplastic astrocytoma is:

Cellular pleomorphism

Increased mitotic activity

Palisading necrosis

Gemistocytes

Explanation:
Palisading necrosis and microvascular proliferation define glioblastoma (WHO grade IV).

8. Pilocytic astrocytoma is most commonly located in the:

Frontal lobe

Temporal lobe

Basal ganglia

Cerebellum

Explanation:
Pilocytic astrocytoma commonly arises in the cerebellum of children.

9. Rosenthal fibers are typically seen in:

Pilocytic astrocytoma

Glioblastoma

Oligodendroglioma

Medulloblastoma

Explanation:
Pilocytic astrocytoma shows Rosenthal fibers and eosinophilic granular bodies.

10. A fourth-ventricular tumor in a child causing obstructive hydrocephalus is most likely:

Central neurocytoma

Ependymoma

Meningioma

Schwannoma

Explanation:
Ependymomas commonly arise in the fourth ventricle in children.

11. The most aggressive pediatric brain tumor listed below is:

Pilocytic astrocytoma

Ependymoma

Medulloblastoma

Dysembryoplastic neuroepithelial tumor

Explanation:
Medulloblastoma is a WHO grade IV tumor with high mitotic activity.

12. The genetic pathway associated with favorable prognosis in medulloblastoma is:

MYC amplification

p53 mutation

EGFR amplification

WNT (β-catenin) pathway

Explanation:
WNT pathway activation is associated with better prognosis in medulloblastoma.

13. A dural-based mass in an adult female is most likely:

Meningioma

Glioblastoma

Metastasis

Ependymoma

Explanation:
Meningiomas are common in adult females and arise from the meninges.

14. Psammoma bodies are commonly associated with:

Schwannoma

Meningioma

Oligodendroglioma

Glioblastoma

Explanation:
Psammoma bodies are concentrically laminated calcifications seen in meningiomas.

15. The most common CNS tumor in immunosuppressed patients is:

Glioblastoma

Metastatic tumor

Primary CNS lymphoma

Ependymoma

Explanation:
Primary CNS lymphoma is most common in immunosuppressed and AIDS patients.

16. Brain metastases most commonly lodge at the:

Basal ganglia

Periventricular region

Cerebellar vermis

Grey-white matter junction

Explanation:
Hematogenous metastases preferentially lodge at the grey-white matter junction.

17. The most common primary tumor to metastasize to the brain is:

Lung carcinoma

Breast carcinoma

Melanoma

Renal cell carcinoma

Explanation:
Lung carcinoma is the most common source of brain metastases.

18. A cerebellopontine angle tumor causing hearing loss is most likely:

Meningioma

Vestibular schwannoma

Ependymoma

Astrocytoma

Explanation:
Vestibular schwannoma (acoustic neuroma) commonly arises at the CPA and causes deafness.

19. Antoni A and Antoni B areas are characteristic of:

Neurofibroma

Meningioma

Schwannoma

Ependymoma

Explanation:
Schwannomas show hypercellular Antoni A and hypocellular Antoni B areas.

20. Intramedullary spinal cord tumors are most commonly:

Meningioma

Schwannoma

Metastatic tumors

Ependymoma and astrocytoma

Explanation:
Intramedullary spinal cord tumors are most commonly ependymomas and astrocytomas.

5# Tumors of CNS

1. The most common intracranial tumor in adults is:

2. The most common intracranial tumor in children is:

3. Tumors that characteristically spread through cerebrospinal fluid include:

4. Homer-Wright rosettes are most characteristic of:

5. A “fried-egg” appearance on histology is typical of:

6. The genetic alteration that predicts good treatment response in oligodendroglioma is:

7. The most important histologic feature that distinguishes glioblastoma from anaplastic astrocytoma is:

8. Pilocytic astrocytoma is most commonly located in the:

9. Rosenthal fibers are typically seen in:

10. A fourth-ventricular tumor in a child causing obstructive hydrocephalus is most likely:

11. The most aggressive pediatric brain tumor listed below is:

12. The genetic pathway associated with favorable prognosis in medulloblastoma is:

13. A dural-based mass in an adult female is most likely:

14. Psammoma bodies are commonly associated with:

15. The most common CNS tumor in immunosuppressed patients is:

16. Brain metastases most commonly lodge at the:

17. The most common primary tumor to metastasize to the brain is:

18. A cerebellopontine angle tumor causing hearing loss is most likely:

19. Antoni A and Antoni B areas are characteristic of:

20. Intramedullary spinal cord tumors are most commonly: